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Gamma-Hydroxybutyric AcidGamma-hydroxybutyric acid (GHB) is a neuroactive molecule that plays a significant role in the brain's regulation of sleep-wake cycles, mood, and learning.
Introduction
GHB is an endogenous ligand that acts on specific GABA receptors, influencing gamma-aminobutyric acid (GABA) neurotransmission. It is primarily found in the hypothalamus and plays a role in regulating circadian rhythms and sleep.
Structure
GHB's structure consists of a four-carbon chain with a hydroxyl group (-OH) attached to the gamma carbon (third carbon from the ketone group). Its chemical formula is C4H8O3.
Metabolism
GHB is metabolized by the enzyme γ-hydroxybutyric acid dehydrogenase (GABDH), which converts it into glutamic acid. This process primarily occurs in the mitochondria and is crucial for maintaining cellular energy levels and regulating amino acid metabolism.
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